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These inflammatory mediators from M1 macrophages and FLSs, in turn, can activate the NF-κB or MAPK pathways in chondrocytes, thereby exacerbating chondrocyte inflammation and further accelerating ECM degradation

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[DOI] [PubMed] [Google Scholar] 8.Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, et al